Sidewalks to Science: Getting to Know Dr. Paula D. Bos, Ph.D. at Virginia Commonwealth University School of Medicine

With lab colleagues at VCU

Dedicating her life to finding a cure for breast cancer, Dr. Paula D. Bos is driven to help Komen meet our Bold Goal of reducing the current number of breast cancer deaths in the U.S. by 50% by 2026. As an Assistant Professor of Pathology, she and members of her lab are dedicated to developing new treatment options for breast cancer patients with metastatic brain tumors.

In this month’s Sidewalks to Science blog, we will get to know Dr. Bos a little better.

When I’m not in the lab I…

  • Enjoy the outdoors with my daughter and husband.
  • Love reading and baking with my daughter.
  • Am an enthusiastic follower of my daughter’s soccer team. As a native Argentinian, I am very passionate about soccer.

Family Picture at the beach

 What I do…targeting immune cells to treat brain metastases.

Although metastatic breast cancer has spread to another part of the body, it’s still considered and treated as breast cancer. Breast cancer that has spread to the brain is treated with breast cancer drugs, rather than treatments for a cancer that began in the brain. However, treatments that work for the primary breast tumor are often ineffective at treating the metastatic brain tumor. Current treatment strategies for brain metastasis, which include surgery and radiation, only offer some improvements for most patients. Therefore, I want to improve the options available to breast cancer patients that have developed brain metastases.

I am investigating how a type of immune cell called a regulatory T (Treg) cell helps breast cancer cells that have spread to the brain grow and survive. Tregs can be found in primary and metastatic breast tumors and correlate with poor patient prognosis. A normal function for Tregs is controlling immune responses, and researchers have shown these cells have the ability to suppress the immune system response against cancer. With my Komen funding, I’m studying how Treg cells support brain metastases. I’m trying to develop a treatment strategy to disrupt the support of breast cancer cells that have metastasized to the brain that could be used in patients.

Breast cancer…touches the lives of so many.

My aunt is a 12-year breast cancer survivor, and other types of cancers have taken dear family members and friends.

Working with patients…motivates my research strategy.

Through my research, I have met and come to admire an incredible group of advocates. Their strength and tireless efforts to bring awareness and increase funding for breast cancer research are a constant incentive to intensify our research efforts.

Dr. Paula Bos

People with breast cancer should…participate in clinical trials!

With new technologies available, science is progressing at a fast pace. We have seen major improvements in the treatment of cancer, especially with the immune system checkpoint blocking antibodies. Breast cancer has yet seen the benefit seen by other cancers, but several approaches are at the clinical trial stage.

Komen is…about patient advocacy!

I have always been motivated to do research to answer pressing clinical needs, but since I started working with patient advocates a few years ago, I now have a better understanding of where the priorities are. Involving advocates allows us to know we are on the right track to discover something of value to the patient community.

“Research is a challenging, expensive, and time-consuming activity. Knowing that patient advocates agree with the goals of our research is reassuring that we are on the right track to discover something of value.”

You can support Dr. Bos and her research by donating directly to her grant here.

If you or a loved one needs information or resources about clinical trials, call our Clinical Trial Information Helpline at 1-877 GO KOMEN (1-877- 465- 6636) or email clinicaltrialinfo@komen.org.

The helpline offers breast cancer clinical trial education and support, such as:

  • Knowing when to consider a trial
  • How to find a trial
  • How to decide which trial is best
  • What to expect during a trial
  • Information about clinical trial resources

Sidewalks to Science: Getting to know Dr. April Kloxin, Ph.D. at the University of Delaware

Dr. Kloxin

Getting to know Dr. April Kloxin, Ph.D. at the University of Delaware

Dedicating her life to finding a cure for breast cancer, Dr. April Kloxin is driven to help us meet our Bold Goal of reducing the current number of breast cancer deaths in the U.S. by 50% by 2026. As an Assistant Professor of chemical and biomolecular engineering, she is addressing the issue of late recurrence for breast cancer survivors.

In this month’s Sidewalks to Science blog, we will get to know Dr. Kloxin a little better.

When I’m not in the lab I…

  • Love to make things! These range from making materials in the lab that mimic tissues in the body to cooking dinner tonight! My favorite quick meals are breakfast foods, which I like any time of day.
  • Love being out in nature, especially hiking. I take my two little ones (two boys, ages four and two) out to our local White Clay Creek Preserve or Longwood Gardens when the weather is nice.
  • Am passionate about solving big problems through science and believe collaboration with others is key.
Dr. Kloxin with Augie and Luke at Longwood Gardens

With my two little ones at Longwood Gardens

What I do…

Study how the environment surrounding breast cancer cells can lead to metastasis

My research group is working to develop materials that mimic the body tissues where breast cancer recurrence is likely to occur. Our team is trying to understand how the environment of these tissues causes dormant breast cancer cells to “wake up”, leading to recurrence.

Breast cancer is…personal to me and my family

My mother is a breast cancer survivor who currently is 13 years disease-free. As a co-survivor, I know firsthand some of the challenges people with breast cancer and survivors face. When my mother was diagnosed, I looked at literature to learn about the latest treatment options for her type of ER+ breast cancer. I realized that patients face a constant concern of recurrence, even after successful initial treatment. Therefore, I decided to focus my research efforts on addressing this outstanding issue of late recurrence.

Dr. Kloxin with student Lisa Sawicki in lab looking at breast cancer cells in 3D culture

With Lisa Sawicki, student, looking at breast cancer cells in 3D culture

Working with patients…has been both motivating and enriching.

Our patient advocate, Kimberly Newman-McCown, provided valuable perspective on the needs of people with breast cancer and kept our work focused on developing tools and finding solutions that will help patients within the next decade.

People with breast cancer should…stay strong and engaged.

Patients and survivors are amazing, and your stories inspire and inform our efforts to find solutions.

Komen is…getting the word out about our research efforts!

I have been excited to engage with our local press to get the word out about our research funded by Komen. This year, I am organizing a team with my research group for the Komen Race for the Cure in Philadelphia, PA.

Family 2017 on vacation in NYC

2017 Family Vacation to NYC’s American Museum of Natural History

Quote…

”Stay strong and engaged! You are amazing and your stories inspire and inform our efforts to find solutions!”

Note: Dr. Kloxin is a Komen grant recipient generously funded by American Airlines.

From Sidewalks to Science: An On-Route Look at Komen’s Research with Dr. Maria Soledad Sosa

Opening Ceremonies

Dr. Sosa, can you tell us a bit about what led you to do breast cancer research?

My mom was diagnosed with ER+ breast cancer 18 years ago. Two years ago, her cancer returned and she needed a second round of treatment. Fortunately, she is doing well. My personal experience with this disease greatly impacted my decision to work in this field, and inspires me every day as I work to make an impact in breast cancer research.

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On the Route

Since we’ve got some time, could you tell us a bit about your current research?

Metastasis (or the spread of breast cancer to other organs) is what kills people with breast cancer. My research is aimed to avoid metastasis before it even begins by targeting the “seeds” of those metastases. These seeds are named DCC (disseminated cancer cells) and are “asleep” in the body, and can be found in important organs like the liver and bones even before a primary tumor is detected. But something causes them to wake up and become aggressive. I believe if we can figure out how these DCCs behave and spread, we might find strategies to eliminate them before they reactivate and form metastases.

At Camp

Now that we’ve made it “home” for the night and are enjoying the support of our crew, can you tell us about how your work would be affected without Komen funding?

Komen funding is imperative to my research. With Komen’s support, I can look for ways to keep these dangerous DCCs “asleep” so they can’t grow and become metastatic tumors. It also allows us to find ways to eliminate DCCs while sleeping. My hope is that this work could someday lead to a cure for metastatic breast cancer.

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Day 2

What would you say to somebody who’s just been diagnosed with breast cancer?

My advice to people would be to have hope and be diligent about your own care. People with no sign of breast cancer should continue to follow-up with their doctor, follow the doctor’s recommendations, and continue to get screened every six to 12 months after treatment has stopped. It was a follow-up screening that helped my mom detect her breast cancer recurrence early. Typically, after a person is treated for breast cancer they are considered to have no sign of breast cancer. However, some people may have DCCs in vital organs that are “asleep.” They could stay like that for years — even decades in the case of ER+ BRCA patients — so it’s important to understand that risk and be proactive about screening. Early detection and follow-up could save the life of a person with no evidence of disease.

Cheering Station

Look at all of these enthusiastic supporters out along the route! Tell us about how you are involved with Komen outside of the lab.

I’m excited to be one of four Komen-funded grantees selected for the Metastatic Breast Cancer (MBC) Research Grant crowdfunding opportunity, where anyone can donate funds to support a research project or researcher of their choice. You can learn more about my story on the Komen Facebook page and donate directly to my Komen-funded MBC research project here!

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Closing Ceremonies

Thanks for walking with us, Dr. Sosa. One final question, in working with patient advocates, how have they impacted your research by bringing the patient perspective?

Sandra Spivey is the patient advocate for my grant, and was so helpful in developing the Letter of Intent and grant proposal. She is very supportive, giving me feedback on how to highlight the patient perspective. I was amazed by her energy and passion. Even when she got sick, she kept working and sending me comments for this grant. I really appreciate all her help, and I am sure she will have a positive impact on my research.

Dr. Maria Sosa is an Assistant Professor at Icahn School of Medicine at Mount Sinai and you can donate to her research project directly through Komen’s crowd funding web page. Since 1982, Susan G. Komen has funded $956 million in breast cancer research, second only to the U.S. government and more than any other nonprofit in the world. Learn more here.

Pit Stop

Three things to know about Dr. Sosa:

  1. I like dancing. And as an Argentinean woman, I dance tango!
  2. In my free time, I love to paint
  3. My family enjoys being outside and being active — doing things like hiking, kayaking, and swimming.

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Grab and Go

Here are three ways you can use this information to help reach your 3-Day fundraising or recruiting goals:

Sample Tweet:

Having seen the effects of breast cancer in her own family, Dr. Maria Soledad Sosa is now conducting research aimed to avoid breast cancer metastasis before it even begins! Learn more about her research here:

Sample Facebook Post:

Having seen the effects of breast cancer in her own family, Dr. Maria Soledad Sosa is now conducting research aimed to avoid breast cancer metastasis before it even begins! Komen funding has been imperative to her research, and she hopes to one day find the cure for metastatic breast cancer! Learn more about her work here: