Sidewalks to Science: Getting to know Dr. April Kloxin, Ph.D. at the University of Delaware

Dr. Kloxin

Getting to know Dr. April Kloxin, Ph.D. at the University of Delaware

Dedicating her life to finding a cure for breast cancer, Dr. April Kloxin is driven to help us meet our Bold Goal of reducing the current number of breast cancer deaths in the U.S. by 50% by 2026. As an Assistant Professor of chemical and biomolecular engineering, she is addressing the issue of late recurrence for breast cancer survivors.

In this month’s Sidewalks to Science blog, we will get to know Dr. Kloxin a little better.

When I’m not in the lab I…

  • Love to make things! These range from making materials in the lab that mimic tissues in the body to cooking dinner tonight! My favorite quick meals are breakfast foods, which I like any time of day.
  • Love being out in nature, especially hiking. I take my two little ones (two boys, ages four and two) out to our local White Clay Creek Preserve or Longwood Gardens when the weather is nice.
  • Am passionate about solving big problems through science and believe collaboration with others is key.
Dr. Kloxin with Augie and Luke at Longwood Gardens

With my two little ones at Longwood Gardens

What I do…

Study how the environment surrounding breast cancer cells can lead to metastasis

My research group is working to develop materials that mimic the body tissues where breast cancer recurrence is likely to occur. Our team is trying to understand how the environment of these tissues causes dormant breast cancer cells to “wake up”, leading to recurrence.

Breast cancer is…personal to me and my family

My mother is a breast cancer survivor who currently is 13 years disease-free. As a co-survivor, I know firsthand some of the challenges people with breast cancer and survivors face. When my mother was diagnosed, I looked at literature to learn about the latest treatment options for her type of ER+ breast cancer. I realized that patients face a constant concern of recurrence, even after successful initial treatment. Therefore, I decided to focus my research efforts on addressing this outstanding issue of late recurrence.

Dr. Kloxin with student Lisa Sawicki in lab looking at breast cancer cells in 3D culture

With Lisa Sawicki, student, looking at breast cancer cells in 3D culture

Working with patients…has been both motivating and enriching.

Our patient advocate, Kimberly Newman-McCown, provided valuable perspective on the needs of people with breast cancer and kept our work focused on developing tools and finding solutions that will help patients within the next decade.

People with breast cancer should…stay strong and engaged.

Patients and survivors are amazing, and your stories inspire and inform our efforts to find solutions.

Komen is…getting the word out about our research efforts!

I have been excited to engage with our local press to get the word out about our research funded by Komen. This year, I am organizing a team with my research group for the Komen Race for the Cure in Philadelphia, PA.

Family 2017 on vacation in NYC

2017 Family Vacation to NYC’s American Museum of Natural History

Quote…

”Stay strong and engaged! You are amazing and your stories inspire and inform our efforts to find solutions!”

Note: Dr. Kloxin is a Komen grant recipient generously funded by American Airlines.

Debbie S. is More Than Pink — Meet a Survivor & New 3-Day Walker

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As our 2018 3-Day season draws closer and closer, we are welcoming past AVON 39 walkers into our 3-Day® family. We want to show them the 3-Day love, because they are a wonderful addition to our cause and they are More Than Pink®.

Debbie S., will also be a proud member of our survivor and those living with metastatic breast cancer community when she joins the San Diego 3-Day in November.

Debbie was officially declared cancer-free in 2005, and since then has been an active crusader for a cure for breast cancer, as well as a staunch supporter and inspiration for those undergoing their own treatment.

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She participated in her first AVON 39 while still bald from her own treatment, and has walked in six AVON 39’s since then. She has also spoken at a breast cancer charity event in Los Angeles, A Cause for Entertainment, and was featured in Avon’s commercial last year. To say she lives to be a part of the fight against breast cancer is an understatement.

“It is so important to keep walking and raising funds for research and awareness! This is what is going to ultimately help cure this disease! Everyone knows about the strides that organizations, such as Susan G. Komen and Avon, have made and I am often asked why other cancers don’t do the same things. My answer is always: They should, you should! Raising funds and awareness is the most important thing!”

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That is why Debbie knew she could not hang up her walking shoes in 2018. She had to keep going, and was excited to join the 3-Day family. Her excitement extends towards fundraising, which she says was one of the things that drew her to the 3-Day in the first place.

“I’m actually most excited about raising more money and walking with others who are doing it for the same reasons I am: a cure! I’m always excited to show everyone how you can beat breast cancer and persevere. Nothing can stop us if we are determined!”

She is determined, in fact, to raise $25,000 this year alone, and has already raised almost $3,000 in the first 24 hours after registering. Though she says she began her fundraising journey with “The mentality that the minimum was enough,” she soon realized that “It is never enough! With every walk, my goal is to beat my last walk!”

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How does she do it? With the same passion and exuberance that has stayed with her throughout her breast cancer journey. She starts via email, sending messages to everyone in her address book (whether she knows them or not!) as well as to any emails she can collect from friends and family. She begins emailing at least six months before her walk, also using social media to kickstart her efforts.

After that, she sends reminder emails to everyone who has not donated on the first of each month. As the event approaches, she will kick it up another notch.

“About two months before the walk, I will start sending it every two weeks. The last month, I will send it every week and eventually daily! I break them all down! They all give! I also upload my letter, with my story, to my personal page for the walk.”

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Simple, but effective, is her approach, and one that has shown great success in the past. This is not just how she approaches fundraising, but how she approaches life in general.

“Being a survivor means everything to me! It means that being strong and having a positive attitude goes a long way! It means I can assure others that they can survive too! Because I am proof!”

If you see Debbie on the 3-Day route in San Diego, say hello and share a hug! She is walking solo this year, but can’t wait to meet new friends and share her story and dream of a world without breast cancer.

Honoring a Mother’s Legacy of Love: Meet Ryan D. of the Philadelphia 3-Day

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“I walk 60 miles so my wife, daughter, friends and those I don’t even know, don’t have to fear this disease. I walk so every grandchild can be spoiled by their grandmothers. I walk today so others will not have to walk tomorrow. I walk because everyone deserves a lifetime.”

Mother’s Day is a chance to honor the women who mean the most to us, whether they are able to celebrate with us or not. For Philadelphia 3-Dayer Ryan D., this means that on Sunday he will not only be celebrating his wife, the mother of his children, but also the mother he lost to breast cancer.

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“Mother’s Day is one of the days I do take time and specifically reflect on my mother and remember all of the great Mother’s Day we celebrated.”

He has been walking “For Mama Doc” since losing her in 2011, spreading her loving and giving spirit with every step he takes. On this holiday, and always, he wants to ensure that no one else loses a mother to breast cancer. The 3-Day, he says, is a new part of his family, and one that helps him remember his mother in the best ways.

“I really wish everyone who has been impacted by this terrible disease could experience a 3-Day at least once, and I can tell you for sure it wouldn’t be their last. It is even hard for me to verbalize what the experience is. There is just something to be said about walking when you are sore and both physically and emotionally spent, to then have a car honk their horn or have someone say, ‘Thank you for walking.’ […] The 3-Days have been some amazing moments of my life.”

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In addition to his 3-Day family, he has been able to share his experience with his brother, who joined Ryan’s mission, and started walking in 2016. They were motivated, in part, to walk together because Philadelphia’s Closing Ceremony that year fell on what would have been their mother’s birthday. They walked all sixty miles together, and each crossed the finish line with their young daughters in their arms. Seeing the 3-Day anew from his brother’s eyes, Ryan says, brought them even closer.

“You can never truly appreciate what a 3-Day truly means until you participate in one. And I saw firsthand the awe on my brother’s face while he walked the first few miles and experienced these things that are so hard to explain.”

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Other family members support them, with Ryan’s dad even walking next to him for a few miles of Ryan’s first ever walk in 2012. They also have helped Ryan raise nearly $25,000 for the 3-Day cause, a landmark he hopes to pass this year. He also looks forward to once again feeling the support of the 3-Day community this fall.

This support is one he especially appreciates given that it was so important to his own mother to support those battling breast cancer. Following her initial recovery from breast cancer in 2009, she mentored countless people suffering from cancer by offering comfort and advice. Though “through the path of recovery there is tremendous uncertainty, fear, pain and self-esteem issues,” Ryan saw his mother provide support, guidance and empathy. This is true to how she lived her whole life, and how Ryan hopes to live his to best honor her legacy.

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“During these last years, my Mom has missed many wonderful events, which include her youngest son’s wedding, witnessing the births of her two beautiful granddaughters and a grandson. I walk to help ensure that no other family misses these special moments with their mothers.”

Ryan walks, and will never quit, for mothers everywhere. Today, and always, hold your family close, and remember that you walk for a reason. You walk for Ryan, for “Mama Doc,” and for families all over the world. And you will never quit either, until we end breast cancer forever.

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